Article
Putative direct and indirect Wnt targets identified through consistent gene expression changes in APC-mutant intestinal adenomas from humans and mice.
Human molecular genetics - 15 Dec 2008
Segditsas Stefania, Sieber Oliver, Deheragoda Maesha, East Phil, Rowan Andrew, Jeffery Rosemary, Nye Emma, Clark Susan, Spencer-Dene Bradley, Stamp Gordon, Poulsom Richard, Suraweera Nirosha, Silver Andrew, Ilyas Mohammad, Tomlinson Ian
Abstract excerpt
In order to identify new genes with differential expression in early intestinal tumours, we performed mRNA (messenger ribonucleic acid) expression profiling of 16 human and 63 mouse adenomas. All individuals had germline APC mutations to ensure that tumorigenesis was driven by 'second hits' at APC. Using stringent filtering to identify changes consistent between humans and mice, we identified 60 genes...
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