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Incomplete MyoD-induced transdifferentiation is associated with chromatin remodeling deficiencies

28 Aug 2017

Abstract excerpt

Our current understanding of cellular transdifferentiation systems is limited. It is oftentimes unknown, at a genome-wide scale, how much transdifferentiated cells differ quantitatively from both the starting cells and the target cells. Focusing on transdifferentiation of primary human skin fibroblasts by forced expression of myogenic transcription factor MyoD, we performed quantitative analyses of gene...

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PMID: 28977539
DOI: 10.1093/nar/gkx773

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