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Article

Genome-wide remodeling of the epigenetic landscape during myogenic differentiation.

Proceedings of the National Academy of Sciences of the United States of America - 31 May 2011

Asp Patrik, Blum Roy, Vethantham Vasupradha, Parisi Fabio, Micsinai Mariann, Cheng Jemmie, Bowman Christopher, Kluger Yuval, Dynlacht Brian David

Abstract excerpt

We have examined changes in the chromatin landscape during muscle differentiation by mapping the genome-wide location of ten key histone marks and transcription factors in mouse myoblasts and terminally differentiated myotubes, providing an exceptionally rich dataset that has enabled discovery of key epigenetic changes underlying myogenesis. Using this compendium, we focused on a well-known repressive mark,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21551099
DOI: 10.1073/pnas.1102223108
PMCID: PMC3107312

Genes

PRC1

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