Article
TEAD transcription factors are required for normal primary myoblast differentiation in vitro and muscle regeneration in vivo.
PLoS genetics - 1 Feb 2017
Joshi Shilpy, Davidson Guillaume, Le Gras Stéphanie, Watanabe Shuichi, Braun Thomas, Mengus Gabrielle, Davidson Irwin
Abstract excerpt
The TEAD family of transcription factors (TEAD1-4) bind the MCAT element in the regulatory elements of both growth promoting and myogenic differentiation genes. Defining TEAD transcription factor function in myogenesis has proved elusive due to overlapping expression of family members and their functional redundancy. We show that silencing of either Tead1, Tead2 or Tead4 did not effect primary myoblast (PM)...
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