Article

Elevated MyoD1 levels expand genome-wide binding and the repertoire of regulated genes

2025-11-14

Abstract excerpt

Transcription factor (TF) upregulation accompanies many cellular state transitions, yet how increased TF abundance impacts gene regulation remains unclear. Two broad models are often invoked, whereby higher TF levels amplify the expression of pre-existing target genes, or, by mass-action binding, expand genome engagement and regulation to lower-affinity sites. We sought to elucidate how these two regulatory modes...

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Literature Corpus work: 76a7a50d-8da3-5be3-b2f8-b8709c990aef
DOI: 10.1101/2025.11.13.688391

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