Article
Correction of the FSHD myoblast differentiation defect by fusion with healthy myoblasts.
Journal of cellular physiology - 1 Jan 2016
Dib Carla, Bou Saada Yara, Dmitriev Petr, Richon Catherine, Dessen Philippe, Laoudj-Chenivesse Dalila, Carnac Gilles, Lipinski Marc, Vassetzky Yegor S
Abstract excerpt
Facioscapulohumeral dystrophy (FSHD) is a neuromuscular disease with a prevalence that could reach 1 in 8,000 characterized by progressive asymmetric muscle weakness. Myoblasts isolated from FSHD muscles exhibit morphological differentiation defects and show a distinct transcription profile. These abnormalities may be linked to the muscle weakness in FSHD patients. We have tested whether fusion of FSHD myoblasts...
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