Article
Conserved Master Regulators Orchestrate Cellular Reprogramming-Induced Rejuvenation
2025-12-01
Abstract excerpt
Partial somatic cell reprogramming has been proposed as a rejuvenation strategy, yet the regulatory architecture orchestrating age reversal remains unclear. Here, we performed gene regulatory network reconstruction across several independent systems to identify master regulators that coordinate reprogramming-induced rejuvenation (RIR). In mouse mesenchymal stem cells, mouse adipocytes, and human fibroblasts underg...
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Identifiers and source
- Literature Corpus work
- 01b20c43-6080-5b57-9a7a-38ce576665b2
- DOI
- 10.1101/2025.11.27.690899