Article

Epigenetic control of myogenic identity of human muscle stem cells in Duchenne Muscular Dystrophy

2023-04-27

Abstract excerpt

In Duchenne Muscular Dystrophy (DMD), the absence of the subsarcolemmal dystrophin protein leads to repeated myofiber damages inducing cycles of muscle regeneration that is driven by muscle stem cells (MuSCs). With time, MuSC regenerative capacities are overwhelmed, leading to fibrosis and muscle atrophy. Whether MuSCs from DMD muscle have intrinsic defects that limit regenerative potential or are disrupted by the...

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Literature Corpus work: 4b1567cb-eb0e-5a69-a1fd-a3ab314e2c54
DOI: 10.1101/2023.04.26.538414

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