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Article

Sdhd ablation promotes thyroid tumorigenesis by inducing a stem-like phenotype.

Endocrine-related cancer - 1 Nov 2017

Ashtekar Amruta, Huk Danielle, Magner Alexa, La Perle Krista, Zhang Xiaoli, Piruat José I, López-Barneo José, Jhiang Sissy M, Kirschner Lawrence S

Abstract excerpt

Mutations in genes encoding enzymes in the tricarboxylic acid cycle (TCA, also known as the Krebs cycle) have been implicated as causative genetic lesions in a number of human cancers, including renal cell cancers, glioblastomas and pheochromocytomas. In recent studies, missense mutations in the succinate dehydrogenase (SDH) complex have also been proposed to cause differentiated thyroid cancer. In order to gain...

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Source

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Identifiers

PMID: 28928232
DOI: 10.1530/ERC-17-0229
PMCID: PMC5650926

Genes

SDHD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Sdhd ablation promotes thyroid tumorigenesis by inducing a stem-like phenotype.PMID 28928232Read ↗

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Dual loss of succinate dehydrogenase (SDH) and complex I activity is necessary to recapitulate the metabolic phenotype of SDH mutant tumors.Semantic proximity Read ↗

Functional succinate dehydrogenase deficiency and loss of ascorbic acid transporter SLC23A1 are pathognomonic adverse features of clear cell renal cancerSemantic proximity Read ↗

Loss of SDHB Promotes Dysregulated Iron Homeostasis, Oxidative Stress, and Sensitivity to Ascorbate.Semantic proximity Read ↗

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