Article
Functional succinate dehydrogenase deficiency is a common adverse feature of clear cell renal cancer.
Proceedings of the National Academy of Sciences of the United States of America - 28 Sept 2021
Aggarwal Ritesh K, Luchtel Rebecca A, Machha Venkata, Tischer Alexander, Zou Yiyu, Pradhan Kith, Ashai Nadia, Ramachandra Nandini, Albanese Joseph M, Yang Jung-In, Wang Xiaoyang, Aluri Srinivas, Gordon Shanisha, Aboumohamed Ahmed, Gartrell Benjamin A, Hafizi Sassan, Pullman James, Shenoy Niraj
Abstract excerpt
Reduced succinate dehydrogenase (SDH) activity resulting in adverse succinate accumulation was previously considered relevant only in 0.05 to 0.5% of kidney cancers associated with germline SDH mutations. Here, we sought to examine a broader role for SDH loss in kidney cancer pathogenesis/progression. We report that underexpression of SDH subunits resulting in accumulation of oncogenic succinate is a common...
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