Article
Loss of SDHB Promotes Dysregulated Iron Homeostasis, Oxidative Stress, and Sensitivity to Ascorbate.
Cancer research - 1 Jul 2021
Goncalves Judith, Moog Sophie, Morin Aurélie, Gentric Géraldine, Müller Sebastian, Morrell Alexander P, Kluckova Katarina, Stewart Theodora J, Andoniadou Cynthia L, Lussey-Lepoutre Charlotte, Bénit Paule, Thakker Alpesh, Vettore Lisa, Roberts Jennie, Rodriguez Raphaël, Mechta-Grigoriou Fatima, Gimenez-Roqueplo Anne-Paule, Letouzé Eric, Tennant Daniel A, Favier Judith
Abstract excerpt
Succinate dehydrogenase is a key enzyme in the tricarboxylic acid cycle and the electron transport chain. All four subunits of succinate dehydrogenase are tumor suppressor genes predisposing to paraganglioma, but only mutations in the SDHB subunit are associated with increased risk of metastasis. Here we generated an Sdhd knockout chromaffin cell line and compared it with Sdhb-deficient cells. Both cell types...
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