Article
Cells silenced for SDHB expression display characteristic features of the tumor phenotype.
Cancer research - 1 Jun 2008
Cervera Ana M, Apostolova Nadezda, Crespo Francisco Luna, Mata Manuel, McCreath Kenneth J
Abstract excerpt
Recently, enzymes of the tricarboxylic acid (TCA) cycle have emerged as novel tumor suppressors. In particular, mutations in the nuclear-encoded subunits of succinate dehydrogenase (SDHB, SDHC, and SDHD) cause paragangliomas and pheochromocytomas. Although the mechanism(s) by which disruption of mitochondrial metabolism leads to neoplasia is largely unknown, increasing evidence points to an activation of...
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