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Article

Cells silenced for SDHB expression display characteristic features of the tumor phenotype.

Cancer research - 1 Jun 2008

Cervera Ana M, Apostolova Nadezda, Crespo Francisco Luna, Mata Manuel, McCreath Kenneth J

Abstract excerpt

Recently, enzymes of the tricarboxylic acid (TCA) cycle have emerged as novel tumor suppressors. In particular, mutations in the nuclear-encoded subunits of succinate dehydrogenase (SDHB, SDHC, and SDHD) cause paragangliomas and pheochromocytomas. Although the mechanism(s) by which disruption of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18519664
DOI: 10.1158/0008-5472.CAN-07-5580

Genes

SDHB
SDHC
SDHD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18519664-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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