Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High Phosphoglycerate Dehydrogenase Expression Induces Stemness and Aggressiveness in Thyroid Cancer

22 May 2020

Abstract excerpt

Background: We examined the changes in glucose metabolites of papillary thyroid cancer (PTC) and identified phosphoglycerate dehydrogenase (PHGDH) as a potential target. The role of PHGDH in the proliferation and tumorigenesis of thyroid cancer cells and its clinical significance were analyzed. Methods: Glucose metabolites of various thyroid tissues were analyzed via targeted metabolomics analysis. In vitro...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Glutathione Transferases and Polymorphisms
Share to Thyroid Cancer Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32438862
DOI: 10.1089/thy.2020.0105

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High Phosphoglycerate Dehydrogenase Expression Induces Stemness and Aggressiveness in Thyroid CancerPMID 32438862Read ↗

Transcriptome Analyses Identify a Metabolic Gene Signature Indicative of Dedifferentiation of Papillary Thyroid CancerSemantic proximity Read ↗

Comprehensive gene expression analysis for exploring the association between glucose metabolism and differentiation of thyroid cancerSemantic proximity Read ↗

Phosphoglycerate dehydrogenase inhibition induces p-mTOR-independent autophagy and promotes multilineage differentiation in embryonal carcinoma stem-like cellsSemantic proximity Read ↗

Comprehensive gene expression analysis for exploring the association between glucose metabolism and differentiation of thyroid cancer.Semantic proximity Read ↗

Integrated metabolic and genetic analysis reveals distinct features of primary differentiated thyroid cancer and its metastatic potential in humansSemantic proximity Read ↗

SGLT2 inhibition restrains thyroid cancer growth via G1/S phase transition arrest and apoptosis mediated by DNA damage response signaling pathwaysSemantic proximity Read ↗

Metformin Targets Mitochondrial Glycerophosphate Dehydrogenase to Control Rate of Oxidative Phosphorylation and Growth of Thyroid Cancer In Vitro and In VivoSemantic proximity Read ↗

PHGDH activation fuels glioblastoma progression and radioresistance via serine synthesis pathwaySemantic proximity Read ↗

Glucose Metabolic Reprogramming in Thyroid Cancer: Underlying Molecular Mechanisms and Links to Progression and Treatment.Semantic proximity Read ↗

SHMT2 promotes thyroid cancer metastasis through epigenetic activation of AKT signalingSemantic proximity Read ↗

Mitochondrial SHMT2 is a crucial therapeutic target in dedifferentiated thyroid cancerSemantic proximity Read ↗

Upregulation of SLC2 (GLUT) family genes is related to poor survival outcomes in papillary thyroid carcinoma: Analysis of data from The Cancer Genome Atlas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.