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A xenograft and cell line model of SDH-deficient pheochromocytoma derived from Sdhb+/− rats

6 Apr 2020

Abstract excerpt

Tumors caused by loss-of-function mutations in genes encoding TCA cycle enzymes have been recently discovered and are now of great interest. Mutations in succinate dehydrogenase (SDH) subunits cause pheochromocytoma/paraganglioma (PCPG) and syndromically associated tumors, which differ phenotypically and clinically from more common SDH-intact tumors of the same types. Consequences of SDH deficiency include...

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PMID: 32252027
DOI: 10.1530/erc-19-0474

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