Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Succinate dehydrogenase inhibition leads to epithelial-mesenchymal transition and reprogrammed carbon metabolism

1 Dec 2014

Abstract excerpt

BACKGROUND: Succinate dehydrogenase (SDH) is a mitochondrial metabolic enzyme complex involved in both the electron transport chain and the citric acid cycle. SDH mutations resulting in enzymatic dysfunction have been found to be a predisposing factor in various hereditary cancers. Therefore, SDH has been implicated as a tumor suppressor. RESULTS: We identified that dysregulation of SDH components also occurs in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer, Hypoxia, and Metabolism
Share to Neuroblastoma Research and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25671108
DOI: 10.1186/2049-3002-2-21

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Succinate dehydrogenase inhibition leads to epithelial-mesenchymal transition and reprogrammed carbon metabolismPMID 25671108Read ↗

Metabolic Effects of Succinate Dehydrogenase Loss in CancerSemantic proximity Read ↗

Succinate Dehydrogenase Complex: An Updated ReviewSemantic proximity Read ↗

Genetic, epigenetic and biochemical regulation of succinate dehydrogenase functionSemantic proximity Read ↗

Loss of SDHB reprograms energy metabolisms and inhibits high fat diet induced metabolic syndromesSemantic proximity Read ↗

Functional succinate dehydrogenase deficiency is a common adverse feature of clear cell renal cancer.Semantic proximity Read ↗

Role of succinate dehydrogenase deficiency and oncometabolites in gastrointestinal stromal tumors.Semantic proximity Read ↗

Molecular Consequences of Pathogenic SDHA Variants: From Defective Flavinylation and Assembly to Lipid RemodelingSemantic proximity Read ↗

SDHB Suppresses the Tumorigenesis and Development of ccRCC by Inhibiting GlycolysisSemantic proximity Read ↗

Dual loss of succinate dehydrogenase (SDH) and complex I activity is necessary to recapitulate the metabolic phenotype of SDH mutant tumors.Semantic proximity Read ↗

Isocitrate dehydrogenase (IDH), succinate dehydrogenase (SDH), fumarate hydratase (FH): three players for one phenotype in cancer?Semantic proximity Read ↗

SDHB reduces chemotherapy resistance in ovarian cancer cells by affecting epithelial mesenchymal transition through DNA damage repairSemantic proximity Read ↗

Metabolic reprogramming and epithelial-to-mesenchymal transition in cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.