Article
SDHB-Deficient Cancers: The Role of Mutations That Impair Iron Sulfur Cluster Delivery.
Journal of the National Cancer Institute - 1 Jan 2016
Saxena Neetu, Maio Nunziata, Crooks Daniel R, Ricketts Christopher J, Yang Youfeng, Wei Ming-Hui, Fan Teresa W-M, Lane Andrew N, Sourbier Carole, Singh Anamika, Killian J Keith, Meltzer Paul S, Vocke Cathy D, Rouault Tracey A, Linehan W Marston
Abstract excerpt
BACKGROUND: Mutations in the Fe-S cluster-containing SDHB subunit of succinate dehydrogenase cause familial cancer syndromes. Recently the tripeptide motif L(I)YR was identified in the Fe-S recipient protein SDHB, to which the cochaperone HSC20 binds. METHODS: In order to characterize the metabolic basis of SDH-deficient cancers we performed stable isotope-resolved metabolomics in a novel SDHB-deficient renal...
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