Article

Functional succinate dehydrogenase deficiency and loss of ascorbic acid transporter SLC23A1 are pathognomonic adverse features of clear cell renal cancer

2020-07-06

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Reduced succinate dehydrogenase (SDH) activity resulting in adverse succinate accumulation was previously thought to be relevant only in 0.05-0.5% of kidney cancers associated with germline SDH mutations (categorized ‘SDH-deficient Renal Cell Carcinoma’ in the 2016 WHO classification) <h4>Results</h4> We show that under-expression of SDH subunits resulting in accumulation...

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Literature Corpus work: 47cc3a7d-d536-51dc-9642-1cdacb0deffe
DOI: 10.1101/2020.07.05.188433

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