Article
Dual loss of succinate dehydrogenase (SDH) and complex I activity is necessary to recapitulate the metabolic phenotype of SDH mutant tumors.
Metabolic engineering - 1 Sept 2017
Lorendeau Doriane, Rinaldi Gianmarco, Boon Ruben, Spincemaille Pieter, Metzger Kristine, Jäger Christian, Christen Stefan, Dong Xiangyi, Kuenen Sabine, Voordeckers Karin, Verstreken Patrik, Cassiman David, Vermeersch Pieter, Verfaillie Catherine, Hiller Karsten, Fendt Sarah-Maria
Abstract excerpt
Mutations in succinate dehydrogenase (SDH) are associated with tumor development and neurodegenerative diseases. Only in tumors, loss of SDH activity is accompanied with the loss of complex I activity. Yet, it remains unknown whether the metabolic phenotype of SDH mutant tumors is driven by loss of complex I function, and whether this contributes to the peculiarity of tumor development versus neurodegeneration....
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