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Article

The BDNF Val66Met polymorphism regulates glucocorticoid-induced corticohippocampal remodeling and behavioral despair.

Translational psychiatry - 19 Sept 2017

Notaras M, Du X, Gogos J, van den Buuse M, Hill R A

Abstract excerpt

The BDNF Val66Met polymorphism has been associated with sensitivity to stress and affective disorders. We therefore sought to model the inter-causality of these relationships under controlled laboratory conditions. We subjected humanized BDNF Val66Met (hBDNFVal66Met) transgenic mice to a history of stress, modeled by chronic late-adolescent corticosterone (CORT) exposure, before evaluating affective-related...

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Source

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Identifiers

PMID: 28926000
DOI: 10.1038/tp.2017.205
PMCID: PMC5639248

Genes

CORT
BDNF
FST
PSD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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