Article
Long-term differential effects of chronic young-adult corticosterone exposure on anxiety and depression-like behaviour in BDNF heterozygous rats depend on the experimental paradigm used.
Neuroscience letters - 25 Jul 2014
Gururajan Anand, Hill Rachel, van den Buuse Maarten
Abstract excerpt
Brain-derived neurotrophic factor (BDNF) has key roles in neurodevelopment and synaptic plasticity and is implicated in affective disorders such as anxiety and depression. The aim of the present study was to use BDNF heterozygous mutant rats (HET) and wildtype controls (WT) to investigate the effect of BDNF downregulation on affective behaviours. We also assessed the longterm effects of young-adult stress, here...
Topics
- Animals
- Anxiety
- Brain-Derived Neurotrophic Factor
- Corticosterone
- Depression
- Genotype
- Heterozygote
- Male
- Maze Learning
- Motor Activity
- Rats, Sprague-Dawley