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BDNF Val66Met genotype and adolescent glucocorticoid treatment induce sex-specific disruptions to fear extinction and amygdala GABAergic interneuron expression in mice.

Hormones and behavior - 1 Aug 2022

Raju Sharvada, Notaras Michael, Grech Adrienne M, Schroeder Anna, van den Buuse Maarten, Hill Rachel A

Abstract excerpt

BACKGROUND: The BDNF Val66Met single nucleotide polymorphism has been implicated in stress sensitivity and Post-Traumatic Stress Disorder (PTSD) risk. We previously reported that chronic young-adult stress hormone treatment enhanced fear memory in adult BDNFVal66Met mice with the Met/Met genotype. This study aimed to extend this work to fear extinction learning, spontaneous recovery of fear, and neurobiological...

Topics

Amygdala
Animals
Brain-Derived Neurotrophic Factor
Calbindin 2
Extinction, Psychological
Fear
Female
Genotype
Glucocorticoids
Interneurons
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Polymorphism, Single Nucleotide

Somatostatin

Source

Identifiers

PMID: 35779519
DOI: 10.1016/j.yhbeh.2022.105231

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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