Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Variant brain-derived neurotrophic factor Val66Met polymorphism alters vulnerability to stress and response to antidepressants.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 21 Mar 2012

Yu Hui, Wang Dong-Dong, Wang Yue, Liu Ting, Lee Francis S, Chen Zhe-Yu

Abstract excerpt

Brain-derived neurotrophic factor (BDNF) plays important roles in cell survival, neural plasticity, learning, and stress regulation. However, whether the recently found human BDNF Val66Met (BDNF(Met)) polymorphism could alter stress vulnerability remains controversial. More importantly, the molecular and structural mechanisms underlying the interaction between the BDNF(Met) polymorphism and stress are unclear. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Corticotropin-Releasing Hormone
Share to Dendritic Spines

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Food Preferences

Share to Proto-Oncogene Proteins c-ets

Share to Pyramidal Cells

Share to Silver Staining

Share to Sweetening Agents

Share to Swimming

Source

Open in PubMed Open full text

Identifiers

PMID: 22442074
DOI: 10.1523/JNEUROSCI.5048-11.2012
PMCID: PMC3319323

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Variant brain-derived neurotrophic factor Val66Met polymorphism alters vulnerability to stress and response to antidepressants.PMID 22442074Read ↗

The BDNF Val66Met polymorphism regulates glucocorticoid-induced corticohippocampal remodeling and behavioral despair.Semantic proximity Read ↗

Behavioral phenotyping of a rat model of the BDNF Val66Met polymorphism reveals selective impairment of fear memory.Semantic proximity Read ↗

Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior.Semantic proximity Read ↗

Acute stress induces an aberrant increase of presynaptic release of glutamate and cellular activation in the hippocampus of BDNFVal/Met mice.Semantic proximity Read ↗

Variant brain-derived neurotrophic factor Val66Met endophenotypes: implications for posttraumatic stress disorder.Semantic proximity Read ↗

A comprehensive review of genetic and epigenetic mechanisms that regulate BDNF expression and function with relevance to major depressive disorder.Semantic proximity Read ↗

Impact of genetic variant BDNF (Val66Met) on brain structure and function.Semantic proximity Read ↗

Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism interacts with gender to influence cortisol responses to mental stress.Semantic proximity Read ↗

Deficit in BDNF does not increase vulnerability to stress but dampens antidepressant-like effects in the unpredictable chronic mild stress.Semantic proximity Read ↗

BDNF variant linked to anxiety-related behaviors.Semantic proximity Read ↗

The BDNF gene Val66Met polymorphism as a modifier of psychiatric disorder susceptibility: progress and controversy.Semantic proximity Read ↗

Brain-derived neurotrophic factor heterozygous mutant rats show selective cognitive changes and vulnerability to chronic corticosterone treatment.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.