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Article

Brain-derived neurotrophic factor heterozygous mutant rats show selective cognitive changes and vulnerability to chronic corticosterone treatment.

Neuroscience - 22 Jan 2015

Gururajan A, Hill R A, van den Buuse M

Abstract excerpt

Brain-derived neurotrophic factor (BDNF) is a widely expressed neurotrophin involved in neurodevelopment, neuroprotection and synaptic plasticity. It is also implicated in a range of psychiatric disorders such as schizophrenia, depression and post-traumatic stress disorder. Stress during adolescence/young adulthood can have long-term psychiatric and cognitive consequences, however it is unknown how altered BDNF...

Topics

Animals
Brain
Brain-Derived Neurotrophic Factor
Conditioning, Psychological
Corticosterone
Disease Models, Animal
Extinction, Psychological
Fear
Genetic Predisposition to Disease
Memory Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Memory, Short-Term

Mutation

Organ Size

Rats, Sprague-Dawley

Rats, Transgenic

Receptor, trkB

Receptors, N-Methyl-D-Aspartate

Recognition, Psychology

Source

Identifiers

PMID: 25445195
DOI: 10.1016/j.neuroscience.2014.10.009

Genes

BDNF
CORT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Brain-derived neurotrophic factor heterozygous mutant rats show selective cognitive changes and vulnerability to chronic corticosterone treatment.PMID 25445195Read ↗

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