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Article

BDNF Val66Met impairs fluoxetine-induced enhancement of adult hippocampus plasticity.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Apr 2012

Bath Kevin G, Jing Deqiang Q, Dincheva Iva, Neeb Christine C, Pattwell Siobhan S, Chao Moses V, Lee Francis S, Ninan Ipe

Abstract excerpt

Recently, a single-nucleotide polymorphism (SNP) in the brain-derived neurotrophic factor (BDNF) gene (BDNF Val66Met) has been linked to the development of multiple forms of neuropsychiatric illness. This SNP, when genetically introduced into mice, recapitulates core phenotypes identified in human BDNF Val66Met carriers. In mice, this SNP also leads to elevated expression of anxiety-like behaviors that are not...

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Identifiers

PMID: 22218094
DOI: 10.1038/npp.2011.318
PMCID: PMC3306891

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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BDNF Val66Met impairs fluoxetine-induced enhancement of adult hippocampus plasticity.PMID 22218094Read ↗

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