Article
Variant brain-derived neurotrophic factor (Valine66Methionine) polymorphism contributes to developmental and estrous stage-specific expression of anxiety-like behavior in female mice.
Biological psychiatry - 15 Sept 2012
Bath Kevin G, Chuang Jocelyn, Spencer-Segal Joanna L, Amso Dima, Altemus Margaret, McEwen Bruce S, Lee Francis S
Abstract excerpt
BACKGROUND: Most anxiety and depressive disorders are twice as common in women compared with men, and the sex difference in prevalence typically emerges during adolescence. Hormonal changes across the menstrual cycle and during the postpartum and perimenopausal periods are associated with increased risk for anxiety and depression symptoms. In humans and animals, reduced brain-derived neurotrophic factor (BDNF)...
Topics
- Alleles
- Analysis of Variance
- Animals
- Anxiety
- Behavior, Animal
- Brain-Derived Neurotrophic Factor
- Disease Models, Animal
- Estrus
- Female
- Mice
- Mutagenesis, Insertional
- Polymorphism, Single Nucleotide
- Sexual Maturation