Article
Effects of FCGRIIIa-158V/F polymorphism on antibody-dependent cellular cytotoxicity activity of adalimumab.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica - 1 Dec 2017
Kimura Koji, Kobayashi Daigo, Hatoyama Saori, Yamamoto Mizuki, Takayanagi Risa, Yamada Yasuhiko
Abstract excerpt
The associations between the efficacy of IgG reagents and the FCGRIIIa-158V/F polymorphism (rs396991) have been investigated. Although the genotype frequencies in healthy Japanese have been reported, those have varied, as one study reported that the proportions of V/V, V/F, and F/F were 59.1%, 38.6%, and 2.3%, respectively, while another study found that they were 4%, 44%, and 52%, respectively. However, there...
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