Article
Fcγ receptor 3B polymorphism is associated with hypersensitivity reactions to adalimumab in Japanese patients with rheumatoid arthritis.
Modern rheumatology - 1 Sept 2017
Tsukamoto Masako, Kameda Hideto, Ohshige Tatsuhiro, Kaneko Yuko, Yoshimoto Keiko, Suzuki Katsuya, Takeuchi Tsutomu
Abstract excerpt
OBJECTIVES: To examine the association between Fcγ receptor (FcγR) polymorphisms and the development of hypersensitivity reactions to adalimumab in patients with rheumatoid arthritis. METHODS: Sixty-five patients receiving adalimumab were enrolled in the study. Genetic polymorphisms for FcγR3B were genotyped in FCGR3B NA1/2 alleles by real allelic discrimination assay. Clinical information and the occurrence of a...
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