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Article

Anti-CD20 rituximab IgG1, IgG3, and IgG4 but not IgG2 subclass trigger Ca2+ mobilization and cytotoxicity in human NK cells.

Journal of leukocyte biology - 1 Oct 2020

Freitas Monteiro Marta, Papaserafeim Maria, Réal Aline, Puga Yung Gisella L, Seebach Jörg D

Abstract excerpt

NK cell-mediated Ab-dependent cellular cytotoxicity (ADCC) is increasingly recognized to play an important role in cancer immunotherapy, transplant rejection, and autoimmunity. However, several aspects of the molecular interactions of IgG subclasses with the Fc-gamma receptor IIIA (FcγRIIIA)/CD16a expressed on NK cells remain unknown. The aim of the current study was to further analyze the role of IgG subclasses...

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Share to Antibody-Dependent Cell Cytotoxicity
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32620047
DOI: 10.1002/JLB.5MA0620-039R

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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