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A critical review of the role of Fc gamma receptor polymorphisms in the response to monoclonal antibodies in cancer

4 Jan 2013

Abstract excerpt

Antibody-dependent cellular cytotoxicity (ADCC) is a major mechanism of action of therapeutic monoclonal antibodies (mAbs) such as cetuximab, rituximab and trastuzumab. Fc gamma receptors (FcgR) on human white blood cells are an integral part of the ADCC pathway. Differential response to therapeutic mAbs has been reported to correlate with specific polymorphisms in two of these genes: FCGR2A (H131R) and FCGR3A...

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PMID: 23286345
DOI: 10.1186/1756-8722-6-1

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