Article
FCGR3A-158 polymorphism influences the biological response to infliximab in Crohn's disease through affecting the ADCC activity.
Immunogenetics - 1 Apr 2013
Moroi Rintaro, Endo Katsuya, Kinouchi Yoshitaka, Shiga Hisashi, Kakuta Yoichi, Kuroha Masatake, Kanazawa Yoshitake, Shimodaira Yosuke, Horiuchi Takahiko, Takahashi Seiichi, Shimosegawa Tooru
Abstract excerpt
An association between FCGR3A-158 V/F polymorphism and biological responses to infliximab has been reported in Crohn's disease (CD) in Western countries. However, little is known about the mechanism by which gene polymorphism affects the responses to infliximab. The aims of this study were to confirm the association in Japanese CD patients and to reveal the effect of gene polymorphism on biological responses to...
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