Article
FcγRIIIa receptor polymorphism influences NK cell mediated ADCC activity against HIV.
BMC infectious diseases - 16 Dec 2019
Talathi Sneha Pramod, Shaikh Nawaj Najir, Pandey Sudhanshu Shekhar, Saxena Vandana Ashish, Mamulwar Megha Sunil, Thakar Madhuri Rajeev
Abstract excerpt
BACKGROUND: HIV-specific Antibody Dependent Cell Cytotoxicity (ADCC) has shown to be important in HIV control and resistance. The ADCC is mediated primarily by natural killer cell activated through the binding of FcγRIIIa receptor to the Fc portion of antibody bound to the antigen expressed on the infected cells. However, no data is available on the influence of the polymorphism in FcγRIIIa receptor on...
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