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Article

Effect of the ADCC-Modulating Mutations and the Selection of Human IgG Isotypes on Physicochemical Properties of Fc.

Journal of pharmaceutical sciences - 1 Sept 2022

Wu Helen Haixia, Crames Maureen, Wei Yangjie, Liu Dongmei, Gueneva-Boucheva Kristina, Son Ikbae, Frego Lee, Han Fei, Kroe-Barrett Rachel, Nixon Andrew, Marlow Michael

Abstract excerpt

Monoclonal antibodies, particularly IgGs and Ig-based molecules, are a well-established and growing class of biotherapeutic drugs. In order to improve efficacy, potency and pharmacokinetics of these therapeutic drugs, pharmaceutical industries have investigated significantly in engineering fragment crystallizable (Fc) domain of these drugs to optimize the interactions of these drugs and Fc gamma receptors (FcγRs)...

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Share to Antibodies, Monoclonal
Share to Antibody-Dependent Cell Cytotoxicity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin Fc Fragments

Share to Immunoglobulin G

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Source

Identifiers

PMID: 35760121
DOI: 10.1016/j.xphs.2022.06.014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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