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Article

Enhancement of the antibody-dependent cellular cytotoxicity of low-fucose IgG1 Is independent of FcgammaRIIIa functional polymorphism.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Sept 2004

Niwa Rinpei, Hatanaka Shigeki, Shoji-Hosaka Emi, Sakurada Mikiko, Kobayashi Yukari, Uehara Aya, Yokoi Haruhiko, Nakamura Kazuyasu, Shitara Kenya

Abstract excerpt

PURPOSE: The most common polymorphic variant of Fcgamma receptor type IIIa (FcgammaRIIIa), FcgammaRIIIa-158F, has been associated with inferior clinical responses to anti-CD20 chimeric IgG1 rituximab compared with FcgammaRIIIa-158V. As we previously found that removal of fucose residues from the oligosaccharides of human IgG1 results in enhanced antibody-dependent cellular cytotoxicity, we compared the effects of...

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Share to Antibodies, Monoclonal, Murine-Derived
Share to Antibodies, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antibody-Dependent Cell Cytotoxicity

Share to Antigens, CD20

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Share to Receptors, IgG

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Source

Identifiers

PMID: 15448014
DOI: 10.1158/1078-0432.CCR-04-0850

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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