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Article

[Influence of FcγRIIIa polymorphism on rituximab-dependent NK cell-mediated cytotoxicity to Raji cells].

Zhongguo shi yan xue ye xue za zhi - 1 Oct 2010

Qu Yu-Hua, Li Yang, Wu Yan-Feng, Fang Jian-Pei, Huang Shao-Liang, Huang Yan, Wei Jing

Abstract excerpt

Fcgamma receptor IIIa (FcγRIIIa) polymorphisms is considered to influence clinical response to therapeutic monoclonal antibody (McAb) in cancer, most people believe it can affect McAb binding, and McAb-dependent NK cell-mediated cytotoxicity. This study was purposed to determine the difference of antibody-dependent cell-mediated cytotoxicity (ADCC) effects mediated by different FcγRIIIa NK cells. The FcγRIIIa...

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Share to Antibodies, Monoclonal
Share to Antibodies, Monoclonal, Murine-Derived

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antibody-Dependent Cell Cytotoxicity

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Share to Killer Cells, Natural

Share to Polymorphism, Genetic

Share to Receptors, IgG

Share to Rituximab

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Identifiers

PMID: 21129274

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