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Article

Identifying topologically associating domains and subdomains by Gaussian Mixture model And Proportion test.

Nature communications - 14 Sept 2017

Yu Wenbao, He Bing, Tan Kai

Abstract excerpt

The spatial organization of the genome plays a critical role in regulating gene expression. Recent chromatin interaction mapping studies have revealed that topologically associating domains and subdomains are fundamental building blocks of the three-dimensional genome. Identifying such hierarchical structures is a critical step toward understanding the three-dimensional structure-function relationship of the...

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Identifiers

PMID: 28912419
DOI: 10.1038/s41467-017-00478-8
PMCID: PMC5599511

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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