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Article

mGlu7 potentiation rescues cognitive, social, and respiratory phenotypes in a mouse model of Rett syndrome.

Science translational medicine - 16 Aug 2017

Gogliotti Rocco G, Senter Rebecca K, Fisher Nicole M, Adams Jeffrey, Zamorano Rocio, Walker Adam G, Blobaum Anna L, Engers Darren W, Hopkins Corey R, Daniels J Scott, Jones Carrie K, Lindsley Craig W, Xiang Zixiu, Conn P Jeffrey, Niswender Colleen M

Abstract excerpt

Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the methyl-CpG binding protein 2 (MECP2) gene. The cognitive impairments seen in mouse models of RTT correlate with deficits in long-term potentiation (LTP) at Schaffer collateral (SC)-CA1 synapses in the hippocampus. Metabotropic glutamate receptor 7 (mGlu7) is the predominant mGlu receptor expressed presynaptically at SC-CA1 synapses in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28814546
DOI: 10.1126/scitranslmed.aai7459
PMCID: PMC5654528

Genes

MECP2

Provenance

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