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Article

A small-molecule TrkB ligand restores hippocampal synaptic plasticity and object location memory in Rett syndrome mice.

Disease models & mechanisms - 1 Jul 2017

Li Wei, Bellot-Saez Alba, Phillips Mary L, Yang Tao, Longo Frank M, Pozzo-Miller Lucas

Abstract excerpt

Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in methyl-CpG-binding protein-2 (MECP2), a transcriptional regulator of many genes, including brain-derived neurotrophic factor (BDNF). BDNF levels are reduced in RTT autopsy brains and in multiple brain areas of Mecp2-deficient mice. Furthermore, experimental interventions that increase BDNF levels improve RTT-like phenotypes in Mecp2...

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Source

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Identifiers

PMID: 28679669
DOI: 10.1242/dmm.029959
PMCID: PMC5536912

Genes

BDNF
MECP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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