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Article

Genetic Reduction or Negative Modulation of mGlu7 Does Not Impact Anxiety and Fear Learning Phenotypes in a Mouse Model of MECP2 Duplication Syndrome.

ACS chemical neuroscience - 19 Sept 2018

Fisher Nicole M, Gogliotti Rocco G, Vermudez Sheryl Anne D, Stansley Branden J, Conn P Jeffrey, Niswender Colleen M

Abstract excerpt

Rett syndrome and MECP2 Duplication syndrome are neurodevelopmental disorders attributed to loss-of-function mutations in, or duplication of, the gene encoding methyl-CpG-binding protein 2 (MeCP2), respectively. We recently reported decreased expression and function of the metabotropic glutamate receptor 7 (mGlu7) in a mouse model of Rett syndrome. Positive allosteric modulation of mGlu7 activity was sufficient...

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Identifiers

PMID: 29227625
DOI: 10.1021/acschemneuro.7b00414
PMCID: PMC6002927

Genes

MECP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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