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Article

Phenotypic profiling of mGlu7 knockout mice reveals new implications for neurodevelopmental disorders.

Genes, brain, and behavior - 1 Sept 2020

Fisher Nicole M, Gould Robert W, Gogliotti Rocco G, McDonald Annalise J, Badivuku Hana, Chennareddy Susmita, Buch Aditi B, Moore Annah M, Jenkins Matthew T, Robb W Hudson, Lindsley Craig W, Jones Carrie K, Conn P Jeffrey, Niswender Colleen M

Abstract excerpt

Neurodevelopmental disorders are characterized by deficits in communication, cognition, attention, social behavior and/or motor control. Previous studies have pointed to the involvement of genes that regulate synaptic structure and function in the pathogenesis of these disorders. One such gene, GRM7, encodes the metabotropic glutamate receptor 7 (mGlu7 ), a G protein-coupled receptor that regulates presynaptic...

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PMID: 32248644
DOI: 10.1111/gbb.12654
PMCID: PMC8034495

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