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Article

Loss and Gain of MeCP2 Cause Similar Hippocampal Circuit Dysfunction that Is Rescued by Deep Brain Stimulation in a Rett Syndrome Mouse Model.

Neuron - 17 Aug 2016

Lu Hui, Ash Ryan T, He Lingjie, Kee Sara E, Wang Wei, Yu Dinghui, Hao Shuang, Meng Xiangling, Ure Kerstin, Ito-Ishida Aya, Tang Bin, Sun Yaling, Ji Daoyun, Tang Jianrong, Arenkiel Benjamin R, Smirnakis Stelios M, Zoghbi Huda Y

Abstract excerpt

Loss- and gain-of-function mutations in methyl-CpG-binding protein 2 (MECP2) underlie two distinct neurological syndromes with strikingly similar features, but the synaptic and circuit-level changes mediating these shared features are undefined. Here we report three novel signs of neural circuit dysfunction in three mouse models of MECP2 disorders (constitutive Mecp2 null, mosaic Mecp2(+/-), and MECP2...

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Source

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Identifiers

PMID: 27499081
DOI: 10.1016/j.neuron.2016.07.018
PMCID: PMC5019177

Genes

MECP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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