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Article

Profiling metabotropic glutamate receptor 7 expression in Rett syndrome: consequences for pharmacotherapy.

Neuroscience - 27 Mar 2026

Vermudez Sheryl Anne D, Freitas Geanne A, Smith Mackenzie, Gogliotti Rocco G, Niswender Colleen M

Abstract excerpt

Rett syndrome (RTT) is caused by mutations in the X-linked methyl-CpG binding protein 2 (MeCP2) transcription factor. RTT patients undergo a developmental regression between 6-18 months of age, resulting in the presentation of symptoms including repetitive behaviors, seizures, autistic-like features, and apneas. We have reported that levels of metabotropic glutamate receptor 7 (mGlu7) are significantly decreased...

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Identifiers

PMID: 41621618
DOI: 10.1016/j.neuroscience.2026.01.040
PMCID: PMC13327099

Genes

MECP2
PAM

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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