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Article

Loss of MeCP2 in cholinergic neurons causes part of RTT-like phenotypes via α7 receptor in hippocampus.

Cell research - 1 Jun 2016

Zhang Ying, Cao Shu-Xia, Sun Peng, He Hai-Yang, Yang Ci-Hang, Chen Xiao-Juan, Shen Chen-Jie, Wang Xiao-Dong, Chen Zhong, Berg Darwin K, Duan Shumin, Li Xiao-Ming

Abstract excerpt

Mutations in the X-linked MECP2 gene cause Rett syndrome (RTT), an autism spectrum disorder characterized by impaired social interactions, motor abnormalities, cognitive defects and a high risk of epilepsy. Here, we showed that conditional deletion of Mecp2 in cholinergic neurons caused part of RTT-like phenotypes, which could be rescued by re-expressing Mecp2 in the basal forebrain (BF) cholinergic neurons...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27103432
DOI: 10.1038/cr.2016.48
PMCID: PMC4897179

Genes

MECP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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