Back to search

Article

Potentiation of the M <sub>1</sub> muscarinic acetylcholine receptor normalizes neuronal activation patterns and improves apnea severity in <i>Mecp2</i> <sup>+/-</sup> mice

2024-04-17

Abstract excerpt

Rett syndrome (RTT) is a neurodevelopmental disorder that is caused by loss-of-function mutations in the methyl-CpG binding protein 2 ( MeCP2 ) gene. RTT patients experience a myriad of debilitating symptoms, which include respiratory phenotypes that are often associated with lethality. Our previous work established that expression of the M 1 muscarinic acetylcholine receptor (mAchR) is decreased in RTT autopsy...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
3a190f4a-b65b-5b67-97a0-a0ba58496de3
DOI
10.1101/2024.04.15.586099
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Potentiation of the M <sub>1</sub> muscarinic acetylcholine receptor normalizes neuronal activation patterns and improves apnea severity in <i>Mecp2</i> <sup>+/-</sup> miceDOI 10.1101/2024.04.15.586099
Loss of MeCP2 Function Across Several Neuronal Populations Impairs Breathing Response to Acute HypoxiaSemantic proximity
Breathing dysfunction in Rett syndrome: understanding epigenetic regulation of the respiratory network.Semantic proximity
mGlu7 potentiation rescues cognitive, social, and respiratory phenotypes in a mouse model of Rett syndrome.Semantic proximity
Profiling metabotropic glutamate receptor 7 expression in Rett syndrome: consequences for pharmacotherapy.Semantic proximity
Respiratory phenotypes are distinctly affected in mice with common Rett syndrome mutations MeCP2 T158A and R168X.Semantic proximity
Profiling metabotropic glutamate receptor 7 expression in Rett syndrome: consequences for pharmacotherapySemantic proximity
Mecp2 Deficiency Disrupts Norepinephrine and Respiratory Systems in MiceSemantic proximity
Selective preservation of cholinergic MeCP2 rescues specific Rett-syndrome-like phenotypes in MeCP2stop mice.Semantic proximity
Loss of MeCP2 in cholinergic neurons causes part of RTT-like phenotypes via α7 receptor in hippocampus.Semantic proximity
Early AMPA receptor potentiation modifies synaptic maturation and disease progression in Rett modelsSemantic proximity
Loss and Gain of MeCP2 Cause Similar Hippocampal Circuit Dysfunction that Is Rescued by Deep Brain Stimulation in a Rett Syndrome Mouse Model.Semantic proximity
Separate respiratory phenotypes in methyl-CpG-binding protein 2 (Mecp2) deficient mice.Semantic proximity
Select a neighboring publication to make it the new centre.