Article

Profiling metabotropic glutamate receptor 7 expression in Rett syndrome: consequences for pharmacotherapy

2025-05-12

Abstract excerpt

We have reported that levels of metabotropic glutamate receptor 7 (mGlu 7 ) are dramatically decreased in brain samples from Rett syndrome patients carrying truncation mutations in the Methyl-CpG Binding Protein 2 ( MECP2 ) gene. Additionally, we identified decreases in mGlu 7 levels in Mecp2 +/- female mice and demonstrated that administration of a positive allosteric modulator (PAM) with activity at mGlu...

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Literature Corpus work: 5074c1a0-44c1-5ed7-a5ed-b6ff83d50b21
DOI: 10.1101/2025.05.08.652716

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