Article
Learning and memory and synaptic plasticity are impaired in a mouse model of Rett syndrome.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 4 Jan 2006
Moretti Paolo, Levenson Jonathan M, Battaglia Fortunato, Atkinson Richard, Teague Ryan, Antalffy Barbara, Armstrong Dawna, Arancio Ottavio, Sweatt J David, Zoghbi Huda Y
Abstract excerpt
Loss-of-function mutations or abnormal expression of the X-linked gene encoding methyl CpG binding protein 2 (MeCP2) cause a spectrum of postnatal neurodevelopmental disorders including Rett syndrome (RTT), nonsyndromic mental retardation, learning disability, and autism. Mice expressing a truncated allele of Mecp2 (Mecp2(308)) reproduce the motor and social behavior abnormalities of RTT; however, it is not known...
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