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Article

Reappraisal of the genetic diversity and pharmacogenetic assessment of CES1.

Pharmacogenomics - 1 Aug 2017

Ferrero-Miliani Laura, Bjerre Ditte, Stage Claus, Madsen Majbritt Busk, Jűrgens Gesche, Dalhoff Kim Peder, Rasmussen Henrik Berg

Abstract excerpt

The CES1 gene encodes a hydrolase that metabolizes important drugs. Variants generated by exchange of segments with CES1P1 complicate genotyping of CES1. Using a highly specific procedure we examined DNA samples from 200 Caucasians and identified 46 single nucleotide variants (SNVs) in CES1 and 21 SNVs in CES1A2, a hybrid composed of CES1 and CES1P1. Several of these SNVs were novel. The frequencies of SNVs with...

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Identifiers

PMID: 28786738
DOI: 10.2217/pgs-2017-0052

Genes

CES1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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