Article

Resolving the <i>CES1</i> Genomic Locus with Cas9-Directed Targeted Long-Read Sequencing for Precision Pharmacogenomics

2025-12-05

Abstract excerpt

<h4>ABSTRACT</h4> Carboxylesterase 1 (CES1) is the primary hepatic hydrolase in humans, crucial for the metabolism of ester-containing drugs and endogenous lipids. However, the CES1 genomic region is difficult to resolve because of adjacent highly homologous pseudogenes and the presence of large structural variants. These complexities often cause read misalignment and inaccurate variant calling with conventional...

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Literature Corpus work: 71aa1776-6e40-59a2-8612-caafb83e3e48
DOI: 10.64898/2025.12.03.692062

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