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Article

A Comprehensive Functional Assessment of Carboxylesterase 1 Nonsynonymous Polymorphisms.

Drug metabolism and disposition: the biological fate of chemicals - 1 Nov 2017

Wang Xinwen, Rida Nada, Shi Jian, Wu Audrey H, Bleske Barry E, Zhu Hao-Jie

Abstract excerpt

Carboxylesterase 1 (CES1) is the predominant human hepatic hydrolase responsible for the metabolism of many clinically important medications. CES1 expression and activity vary markedly among individuals; and genetic variation is a major contributing factor to CES1 interindividual variability. In this study, we comprehensively examined the functions of CES1 nonsynonymous single nucleotide polymorphisms (nsSNPs)...

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Source

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Identifiers

PMID: 28838926
DOI: 10.1124/dmd.117.077669
PMCID: PMC5637814

Genes

CES1

Variants

rs202121317
rs151291296
rs151291296
rs202121317

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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