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Article

Regulatory effects of genomic translocations at the human carboxylesterase-1 (CES1) gene locus.

Pharmacogenetics and genomics - 1 May 2016

Sanford Jonathan C, Wang Xinwen, Shi Jian, Barrie Elizabeth S, Wang Danxin, Zhu Hao-Jie, Sadee Wolfgang

Abstract excerpt

OBJECTIVE: CES1 encodes carboxylesterase-1, an important drug-metabolizing enzyme with high expression in the liver. Previous studies have reported a genomic translocation of the 5' region from the poorly expressed pseudogene CES1P1, to CES1, yielding the structural variant CES1VAR. The aim of this study was to characterize this translocation and its effect on CES1 expression in the human liver. MATERIALS AND...

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Share to 5' Untranslated Regions
Share to Carboxylic Ester Hydrolases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Genetic Variation

Share to Hep G2 Cells

Share to Promoter Regions, Genetic

Share to Translocation, Genetic

Source

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Identifiers

PMID: 26871237
DOI: 10.1097/FPC.0000000000000206
PMCID: PMC4821783

Genes

CES1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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