Article
Carboxylesterase 1 genes: systematic review and evaluation of existing genotyping procedures.
Drug metabolism and personalized therapy - 28 Mar 2018
Rasmussen Henrik Berg, Madsen Majbritt Busk
Abstract excerpt
The carboxylesterase 1 gene (CES1) encodes a hydrolase that metabolizes commonly used drugs. The CES1-related pseudogene, carboxylesterase 1 pseudogene 1 (CES1P1), has been implicated in gene exchange with CES1 and in the formation of hybrid genes including the carboxylesterase 1A2 gene (CES1A2). Hence, the CES1 region is complex. Using in silico PCR and alignment, we assessed the specificity of PCR-assisted...
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